Upper Respiratory Tract Infections (URTI) can be caused by more than 200 different viruses, and it is estimated that the U.S. population suffers more than one billion colds a year (2-4 per average adult, 6-10 per average child). A number of lifestyle factors contribute to URTI risk, including poor nutrient status, lack of sleep, and stress. A new paper published in the British Journal of Sports Medicine adds exercise habits to the list of lifestyle factors affecting URTI risk.

1,023 subjects between 18 and 85 years of age were recruited for this study, with 1,002 individuals completing all study requirements. Subjects were selected from multiple BMI groups (roughly one-third were of normal weight, one-third were overweight, and one-third were obese) to ensure adequate representation. A comprehensive validated survey on lifestyle, diet, activity levels, stress, and URTI incidence and severity was completed by each study participant.

After controlling for potential cofounders, total days with URTI symptoms were 43-46% lower in the highest third of aerobic activity when compared to the lowest third, while URTI severity was reduced 32-41% for the high group. Low stress levels, high exercise frequency (≥5 days/week), and high fruit intake (≥3 servings/day) also correlated with reduced URTI incidence.

The exact mechanism by which aerobic exercise reduces URTI risk is still uncertain, although it appears to be a combination of factors, including transient increases of certain immune cell types, a reduction of stress hormones, and specialized benefits to key organs (particularly the lungs, which serve as a primary barrier against URTIs).

Nieman DC, Henson DA, Austin MD, Sha W. Upper respiratory tract infection is reduced in physically fit and active adults. 2010. Br J Sports Med, ePub ahead of print. doi:10.1136/bjsm.2010.077875

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In a recent study, lower magnesium levels correlated with an increased number of metabolic syndrome risk factors.

Metabolic syndrome has been defined as the presence of abdominal obesity combined with two of the following factors: hypertension, dyslipidemia, impaired glucose tolerance, or diabetes mellitus. Magnesium is an essential cofactor for more than 300 enzymes involved in carbohydrate and lipid metabolism.

In a recent study, researchers enrolled 117 overweight and obese patients and measured serum magnesium levels together with fasting serum glucose, high-density lipoprotein cholesterol (HDL), and triacylglycerols. Researchers found a strong inverse relationship between serum magnesium levels and the presence of metabolic syndrome. In addition, as the level of serum magnesium decreased, the number of factors relating to metabolic syndrome increased. Also, there was an inverse relationship between serum magnesium levels and high-sensitivity C-reactive protein (a marker of inflammation).

The scientists concluded that decreased levels of serum magnesium are associated with increased risk for metabolic syndrome, possibly due to a low-grade inflammatory process.

Angelos A, et al. An inverse relationship between cumulating components of the metabolic syndrome and serum magnesium levels. 2008. Nutrition Research 28(10):659-63.

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Summary:
A recent study demonstrates an association between maternal vitamin B12 status during pregnancy and children’s cognitive functioning at age 9. Higher maternal plasma vitamin B12 concentration in pregnancy was an independent predictor of the child’s cognitive performance.

Details:
Vitamin B12 is an important nutrient for brain development and function. Since fetal requirements are provided by the mother through the placenta, inadequate maternal levels directly affect the amount available to the fetus. Research has consistently shown that maternal nutritional status can influence metabolic, cardiovascular, and psychiatric health of their future children.

In a recent study, investigators analyzed the relationship between maternal plasma vitamin B12 status during pregnancy and the child’s cognitive function at 9 years of age. Previous research had shown that maternal vitamin B12 status influenced intrauterine growth and insulin resistance in children at 6 years of age.

Subjects included two groups of children born in the Pune Maternal Nutrition Study. The two groups were selected based on the maternal plasma vitamin B12 concentration at 28 weeks of gestation. Group 1 included 49 children born to mothers with the lowest plasma levels of vitamin B12. Group 2 included 59 children born to mothers with the highest plasma levels of B12.

The differences in tested intelligence and visual agnosia (the ability to recognize shapes, people, sounds, smells, and objects) were not significantly different between the groups. However, children from group 2 performed significantly better on a test for sustained attention and on a test of short-term memory. The differences were still significant after appropriate adjustments for confounding factors.

Result of this study support the idea that maternal vitamin B12 status in pregnancy influences cognitive function in offspring.

Bhate V, et al. Vitamin B12 status of pregnant Indian women and cognitive function in their 9-year-old children. 2008. Food Nutr Bull 29(4): 249–54.

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